Top Nerve Pain Relief Supplements for Neuropathy 2021 Review

Diabetes is a serious health issue that works to disrupt the body’s food-energy conversion process. The majority of the food you eat is converted into sugar (also known as glucose) and delivered into your bloodstream. When your blood sugar rises, your pancreas sends a signal to release insulin. Insulin functions as a key to allow blood sugar into your body’s cells for usage as energy. It can lead to a variety of consequences if not treated and managed correctly. Neuropathy is one such issue.

Diabetic neuropathy is a type of diabetes complication that causes nerve damage. It is a progressive condition with worsening symptoms over time. Approximately 65 percent of all people with diabetes have some form of nerve injury, resulting in diabetic neuropathy. In the United States, diabetes is the major cause of neuropathy. Many people nowadays take nerve health supplements to aid with neuropathy. Some nerve health supplements have been shown to aid with pain, inflammation, and other neuropathy symptoms. With so many nerve health pills on the market, it’s challenging to determine which one is best for you. This is where we can help.

Please continue reading to learn more about neuropathy and its supplements.

What exactly is Neuropathy?

Neuropathy is a chronic illness caused by nerve injury or compression outside of the spinal cord and brain. It happens when your nerves are injured or destroyed. Nerves transmit information from your body to your brain. When these nerves are damaged or killed, they transmit erratic messages to your brain, leading you to experience pain, numbness, or tingling. Neuropathies commonly begin in the hands and feet, but other body areas might be affected as well. In most cases, it occurs when high quantities of lipids or sugar in the blood harm the body’s neurons. It can affect almost any nerve in the body, resulting in a wide range of symptoms. Tingling, discomfort, or numbness in your extremities might be caused by neuropathy. People with diabetes are prone to neuropathy. Neuropathy, often known as peripheral neuropathy, is a condition with the peripheral nervous system. That is why Neuropathy is often referred to as “Peripheral Neuropathy.”

What causes Neuropathy?

Neuropathy can occur for a variety of reasons, including diabetes. Some people get neuropathy as a result of nerve injury, for example. It is a genetic condition in others. Among the known causes are:

The most prevalent cause of neuropathy is physical harm to the region. For example, you could have an accident, a fall, or a sports injury. Others get neuropathy as a result of a broken or dislocated bone.

Repetitive movements that occur throughout time can also cause neuropathy. Neuropathy is a kind of carpal tunnel syndrome. Repetitive actions, mainly when performed poorly, can cause nerve injury over time.

Diabetes is the leading cause of neuropathy in the United States. Neuropathy affects around 70% of diabetics at some level of severity. Neuropathy is more likely to occur if you have diabetes for a long time.

Vascular difficulties, blood disorders, and circulatory disruptions are all possible causes. When your blood does not circulate adequately to your peripheral nerves, it deprives those nerves of oxygen, causing nerve tissue damage.

Tobacco usage can cause or raise the risk of acquiring neuropathy. Smoking constricts blood arteries and has been linked to elevated blood pressure.

Complications associated with neuropathy include:

  • Autoimmune disorders and diseases
  • Kidney and liver diseases
  • Hormonal imbalances
  • Cancer
  • Chemotherapy drugs
  • Infections

How do Neuropathy supplements function?

Neuropathy supplements act in a variety of ways. Some promote blood flow and inflammation, assisting your body in dealing with the underlying causes of neuropathy. Others pump your body with amino acids, herbal extracts, plant extracts, and other neuropathy-relieving ingredients. The mechanism of action of all neuropathy support supplements is determined by the particular active components employed in their formulation. The active substances are those that directly treat neuropathy and its related symptoms. Other components only have mechanical effects such as assisting penetration, having a pleasant texture, having a better fragrance, etc. Most neuropathy support supplements contain a plethora of active substances.

Best Nerve Supplements of 2021

Let’s get right into it and look at the best supplements for neuropathy in 2021 to see which are the best nerve health support solutions on the market today!

Nerve Control 911


Nerve Control 911 by PhytAge Labs claims to manage nerve pain associated with diabetes and other illnesses using all-natural substances. Certain symptoms of nerve discomfort can be relieved by taking two capsules daily. It also promises to assist in enhancing the body’s muscles, govern voluntary motions and reflexes, carry information from the central nervous system to the rest of the body, and reduce inflammation, among other things. Natural components such as marshmallow root and passionflower are prominent in Nerve Control 911. One element in Nerve Control 911 is described by PhytAge Labs as a “wonder root” from Malaysia.

Nuturna Maximum Strength Neuropathy Support Formula

Nuturna Maximum Strength Neuropathy Support Formula IMAGE

The Nuturna Maximum Strength Neuropathy Support Formula, which costs less than $43 on Amazon, targets nerve pain with alpha-lipoic acid, L-arginine, benfotiamine, turmeric, and herbal extracts. Its recipe contains some of the most potent doses. For example, each four capsule serving provides 600mg of ALA, which is a larger amount than most other supplements on this list. Many neuropathy pills include the correct components — but in the incorrect amounts. The Nuturna Maximum Strength Neuropathy Support Formula is a potent blend of 18 herbs, vitamins, and minerals that attack nerve pain in a variety of ways.



The Nervala pill from Barton Nutrition is marketed as the “key to getting rid of tingling, numbness, [and] shooting agony.” Nervala works by “cooling down” your nerves, keeping them from “overheating” and causing nerve discomfort. Nervala fights inflammation all over your body. Its components promote good inflammation by focusing on free radicals. Free radicals are responsible for oxidation and inflammation throughout your body. Nervala can maintain healthy inflammation by targeting and neutralizing free radicals, assisting some patients with neuropathy. Nervala has only two active ingredients: 75mg of benfotiamine and 600mg of alpha-lipoic acid per serving.

Nerve Renew


Nerve Renew by Life Renew relieves neuropathy by utilizing B vitamins and alpha-lipoic acid. You take two capsules twice a day to treat nerve damage. Nerve Renew works by infusing antioxidants into the nerve injury, hence alleviating nerve pain, numbness, and discomfort in the affected area. Nerve Renew’s comprehensive ingredient list contains vitamins B1, B2, B6, B12, and D, among others. Because of its innovative delivery mechanism, Life Renew claims that its solution is absorbed three times faster by the body than competing neuropathy supplements. Simply take Nerve Renew daily for natural nerve healing, fast-acting pain relief, a natural energy boost, and numbness and tingling relief.

Nerve Rejuv


Golden After 50’s Nerve Rejuv is a neuropathic supplement sold to older persons suffering from nerve discomfort, including diabetics and non-diabetics. You can ostensibly avoid the discomfort, numbness, and tingling associated with neuropathy by taking two capsules of Nerve Rejuv daily. Golden After 50 has added alpha-lipoic acid, turmeric, and other components to its mix to attain these effects. These components are said to help your body rebuild nerve ends, allowing you to prevent neuropathy pain. The minerals, vitamins, herbal extracts, and amino acids in Nerve Rejuv are said to relieve nerve pain in various methods. Golden After 50 particularly states that the mixture can aid with the pain associated with fibromyalgia, shingles, and other diseases, elevating it above the level of another diabetic nerve pain supplement.



Nervexol is intended to reduce and remove nerve discomfort. It contains alpha-lipoic acid, coenzyme Q10 (CoQ10), vitamin B1, and calamarine as components. Although other substances have B vitamins to aid in neuropathy treatment, Nervexol is one of the few neuropathy supplements that contain calamarine. It is a deepwater squid that lives off the coast of South America. It’s high in omega-3 fatty acids, which can help with brain, joint, and eye health. Nervexol contains calamarine and other special substances that can strengthen and nourish the nerves, offer you a good night’s sleep, and reduce numbness, burning, stinging, and tingling sensations in your hands, feet, and legs.

Circle Labs CBD


Circle Labs CBD sells CBD balms, tinctures, and creams that may help alleviate diabetic nerve pain. Many people use CBD regularly to help with neuropathy. It is the only natural treatment that works for certain people. CBD functions by interacting with your body’s endocannabinoid system, which includes your CB1 and CBD2 receptors. These receptors can be present in cells all over your body. Circle Labs sells CBD products such as CBD Pain & Tension Balm, 3x Strength CBD Pain Stick, and CBD/CBDa tinctures and oils. You can assist your body recover nerve function by applying or consuming these nutrients daily. Some report that Circle Labs CBD products effectively treat neuropathy and nerve pain symptoms. Circle Labs’ CBD may be the ideal choice if you want a unique option for neuropathy and haven’t found relief with other nerve pain supplements on this list.

Nuturna Clinical Strength Neuropathy 900


Clinical Strength Neuropathy 900 by Nuturna is specifically intended to treat neuropathy. Neuropathy 900, like other Nuturna products, contains high concentrations of all active components. Each meal contains 900mg of alpha-lipoic acid, as well as significant amounts of L-arginine, acetyl-L-carnitine, organic turmeric root, and other plant and herbal extracts. Clinical trials normally utilize 300mg to 900mg of ALA per day, and Nuturna provides a dose on the higher end of that range. Nuturna’s Clinical Strength Neuropathy 900 has a total of 18 substances that address nerve pain and immunological health.

Neuro Calm Pro


The first product on this list, Neuro Calm Pro, promotes nerve health by focusing on your ears. It uses natural substances to relieve neuropathy and nerve pain by soothing inflamed and injured nerves. It soothes irritable nerves with substances like fenugreek extract, saw palmetto, L-tyrosine, and wild yam. Neuro Calm Pro may be of assistance if you suffer from tinnitus, nerve discomfort, or general tingling and numbness in your extremities. The company also sells a product called Neuro Deep Calm, which is said to have comparable advantages. As part of a recent promotion, all orders now include a digital sound treatment protocol, which will assist you in using audio therapy to ease irritable nerves.

Nervogen Pro


Nervogen Pro targets neuropathy by delivering modest amounts of five active substances. It contains passionflower extract, marshmallow root extract, corydalis extract, prickly pear extract, and California poppy seed extract. These compounds can alleviate nerve pain, numbness, tingling, and other symptoms. Because of dosage concerns, Nervogen Pro is at the bottom of our list. Nervogen Pro lacks the dosage of its more effective competitors, with only 145mg of passionflower and less than 110mg of each of the other components.

Bonus Nerve Pain Guide #1: Neuropathy No More


Neuropathy No More is a new eBook from Blue Heron Health News. The eBook, published by Jodi Knapp, is based on the premise that neuropathy is a choice, not a life sentence. According to the author, by following the instructions in this eBook, you can reportedly “choose to be free of neuropathy.” It suggests that you modify your food and lifestyle to address your neuropathy. Simple lifestyle changes, rather than medicines or technology, may provide relief. Neuropathy No More may not be suitable for everyone. On the other hand, the guide is supported by a 60-day return policy, which allows you to earn a full refund if Jodi Knapp’s treatment plan does not work for you.

Bonus Nerve Pain Guide #2: Neuropathy Revolution

Neuropathy Revolution is a nerve pain treatment program that claims to eliminate diabetic nerve pain in 30 days. According to the author, a seven-step holistic technique will relieve chronic peripheral neuropathy and diabetic nerve pain “in as little as 24 hours.” The guide claims to be beneficial for all levels of nerve pain severity. In addition, the authors of Neuropathy Revolution have packaged their program with an eBook called Diabetes Protocol as part of a 2021 offer. That eBook claims to employ holistic tactics to “treat and repair the root cause of type 2 diabetes.” According to author Mark Fellers, after purchasing Neuropathy Revolution, you may experience relief from neuropathy and diabetes. It also comes with a full refund option.

Most often used active components and functions for Nerve Supplements


It’s one of the most commonly used components in neuropathy supplements. Your liver and kidneys naturally produce Acetyl-L-carnitine. Some people take acetyl-L-carnitine supplements daily to help with physical and mental energy. Certain modest studies suggest that acetyl-L-carnitine supplementation may assist with some neuropathy symptoms. Researchers discovered evidence that acetyl-L-carnitine could improve nerve function in persons with diabetic neuropathy in this review.

Vitamin B6/B12

The majority of neuropathy pills also include B vitamins. Some contain B6 and B12 vitamins. Others include a particular combination of B complex vitamins. Researchers discovered that vitamin B12 deficiency was connected to nerve dysfunction and other health concerns in this 2014 study. They also discovered that neuropathy caused by vitamin B12 deficiency usually starts in the foot. If you are lacking in vitamin B12 and have neuropathy, a vitamin B12 supplement may be beneficial. Researchers investigated the effect of vitamin B6 on neuropathy, determining that a lack of vitamin B6 can cause numbness or searing sensation in the feet, spreading to the legs and ultimately the hands. If you lack vitamin B6, vitamin B6 pills, like vitamin B12 supplements, may assist promote nerve health.

Alpha lipoic acid (ALA)

It is an antioxidant-like substance that can be found in numerous neuropathy supplements marketed on the internet nowadays. Several studies have shown that ALA reduces the burning and stabbing symptoms associated with neuropathy – often within a few weeks. In this 2006 study, for example, researchers administered participants 600mg, 1,200mg, or 1,800mg of alpha-lipoic acid per day for five weeks before testing the results. Researchers discovered that at all three levels, patients reported fewer symptoms than a placebo, while those in the upper dosage range reported more adverse effects. Similarly, 300mg of alpha-lipoic acid-enhanced blood flow to the upper arm while also lowering inflammation, both of which could aid with neuropathy.


Magnesium, according to some, can aid with relieving neuropathy. According to the Foundation for Peripheral Neuropathy, magnesium may aid with chemotherapy-related neuropathy, while a further large-scale study is needed to confirm this link. This study published in Nutrients discovered that patients undergoing chemotherapy had fewer symptoms of neuropathy when their magnesium levels were greater, implying that magnesium affects neuropathy in some way. However, a 2013 study found no link between neuropathy and magnesium.


The amino acid is the most abundant in the human body. According to research, it may help with specific types of neuropathy by reducing inflammation, muscle pain, and numbness or tingling. Glutamate can be obtained via a neuropathy supplement or a glutamine supplement. Wheat, peanuts, corn, soybeans, milk, egg whites, and other foods also contain it. Researchers discovered that glutamine could eradicate or minimize the degree of neuropathy in chemotherapy patients in this review study.


It is an antioxidant mainly found in an increasing number of neuropathy supplements. Early research suggests that glutathione may aid in treating a variety of neuropathies, including chemotherapy-related neuropathy, diabetic neuropathy, and various types of neuropathy associated with other illnesses. The problem with glutathione is absorption: your body breaks down most glutathione before it is taken, making it challenging to take glutathione supplements.

Factors on which we ranked the nerve supplements

Every neuropathy supplement promises to be effective in relieving nerve pain. Unfortunately, however, many supplements are ineffective. Some are made with dubious ingredients. Others have the proper chemicals but at too low a dose to affect the human body.

We utilized the following ranking variables to distinguish between the best and worst nerve pain supplements:

Clinically Proven Ingredients

Millions of people worldwide suffer from peripheral neuropathy. Researchers have studied herbal extracts, botanicals, vitamins, minerals, and other nutrients to discover how they affect neuropathy for decades. We picked neuropathy pills that had only the greatest, most clinically validated substances.

Effective Doses

Some neuropathy supplements include the correct components but at the incorrect dosages. Some doses are shallow. Other companies refuse to publish dosage information instead of concealing low amounts with proprietary formulae. We preferred supplements with doses that were comparable to those used in clinical trials and scientific investigations.

Price & Value

Neuropathy supplements range in price from $20 to $100. We offered neuropathy supplements in a variety of price ranges. We did, however, stress good value at all prices. You can select a neuropathy treatment program that fits your budget, whether it is a few dollars or a few hundred dollars.

Honest Advertised Benefits

Some diabetic nerve pain pills claim to treat diabetes, erase neuropathy, and fix all of your health issues. Others are more forthright about their benefits, suggesting that they improve nerve health and assist your body to maintain appropriate blood sugar levels, among other things. Supplements cannot legally claim to treat or prevent diseases. Some supplement firms toe the line (or overstep it), while others are more forthright.

Transparent Labels

It is critical to have clear supplement labeling. If you have a condition like diabetes, you must be cautious about what you put into your body. Some supplement firms provide a complete list of components and dosages upfront. Others merely reveal a subset of the ingredients. Some conceal dosages under proprietary labels, making comparisons to other supplements or scientific research impossible.

Manufacturer Reputation & Location

Some supplement firms reveal just a limited amount of information about themselves, their manufacturing location, and the sources of their ingredients. Well-known supplement companies manufacture other neuropathy supplements. We favored well-known manufacturers over lesser-known suppliers.

Medical Advisory Board

Medical doctors, naturopathic doctors, accredited nutritionists, and other health and wellness professionals serve on the medical advisory boards of the leading supplement firms. Some supplement businesses have enlisted the services of a medical advisory board. Any medical advice does not support others.

Proven Benefits

The best neuropathy supplements are effective. They alleviate tingling, numbness, and discomfort in the limbs. Some jobs are completed in a matter of days. Others begin working after a few weeks. Some do not function at all. To determine the effectiveness of each supplement, we tested formulae, analyzed online consumer evaluations, and used other measures.

Benefits of Neuropathy Supplements

Neuropathy support supplement includes a wide range of nerve and non-nerve-related interests. In certain circumstances, their advantages outweigh those of pharmaceutical medications. This section will showcase a few of these advantages:

Nerve Repair

These supplements’ active ingredients are intended to stimulate the repair of damaged nerve cells and the growth and normal functioning of healthy ones. They also support nerve function, such as conduction velocity, and improve nerve tissue myelination for protection. Neuropathy support supplements, in addition to nerve regeneration, give significant alleviation for neuropathy-related symptoms such as numbness, tingling, burning, sensitivity, and other painful sensations.

Removal of Toxins

Neurotoxins and other free radicals are both indicators of nerve injury and boosters of it. They are frequently the result of cellular metabolism. Potent antioxidants in neuropathy support supplements reduce the development and impact of neurotoxins and other free radicals in nerve cells.

General Body Nutrition

Many elements in neuropathy support supplements, including vitamins and minerals, provide overall sustenance for the body. Vitamin B12, for example, is required for the formation of blood-red cells, which transport oxygen for cellular metabolism.

Furthermore, Alpha Lipoic Acid and L-Carnitine are potent antioxidants that lower the danger of health risks associated with oxidative stress. Other plants, such as Aloe Vera, give nutrition for the body, and topical supplements boost the skin’s overall health.

Recommended Dosage Guide

When it comes to vitamins, the most challenging part is determining the proper dosage. You must not exceed the recommended dosage because doing so will have negative consequences. When herbs are utilized in supplements, determining the optimum dosage becomes much more challenging. However, seek the recommended dosage on the medicine label or contact the manufacturer for more information.

Neuropathy Supplements in light of Science

The majority of neuropathy supplements have not been subjected to clinical studies. Individual compounds in neuropathy supplements, on the other hand, have a lot of research backing them up, as explained above. Other methods of managing neuropathy have been discovered by researchers, including dietary and lifestyle changes.

Controlling blood sugar, having a shingles vaccine, engaging in physical exercise, and lowering inflammation have all been shown in studies to aid with neuropathy. Quitting smoking, if you smoke, may assist with neuropathy because it improves blood flow.

Anything that enhances blood flow or lowers inflammation may be beneficial in the treatment of neuropathy. Finally, neuropathy can be a serious ailment, and it is critical to consult with a doctor to manage the problem – especially if neuropathy symptoms are unbearable or worsening. Supplements may not assist if you have severe neuropathy. In that case, more serious therapies like surgery may be required.

Nerve Supplement FAQs

Q: What is the distinction between mononeuropathy and polyneuropathy?

A: When a single nerve is affected, the ailment is referred to as mononeuropathy; when numerous nerves are affected, the condition is referred to as polyneuropathy.

Q: What are the signs and symptoms of neuropathy?

A: Numbness, discomfort, burning, tingling, and weakness in the hands and feet are the most frequent neuropathy symptoms. Some people get neuropathy as they progress up their arms and legs. If you’ve ever had a case of the ‘pins and needles,’ you’ll understand how neuropathy feels.

Q: How do physicians treat neuropathy?

A: Depending on your situation, your doctor may offer a different treatment for neuropathy. Some doctors advise taking pain relievers and engaging in physical therapy. Others advice applying for topical medicines or using laser therapy. Many treatments just address neuropathy symptoms without treating the underlying cause, which is why many neuropathy pills market themselves as long-term support supplements that address the underlying reason.

Q: What is the procedure for neuropathy surgery?

A: Nerve decompression surgery is another name for neuropathy surgery. The surgery, which is performed as an outpatient procedure, releases compression sites along the nerve. These pressure spots may be the source of your neuropathy symptoms.

Q: Why do different persons experience neuropathy differently?

A: Neuropathy, like most nerve disorders, is a complicated condition. It has varied effects on different people. Depending on how your nerve transmission has been disturbed, you may experience a variety of neuropathy symptoms. The three primary nerve signaling abnormalities associated with neuropathy are as follows:

  • Signals that are routinely sent are lost (think of a broken wire)
  • When there should be no signaling, there is inappropriate signaling (think of static on a telephone line)
  • Incorrect signaling that alters the messages sent (like a distorted television picture)

Q: Does neuropathy cause pain?

A: Neuropathy pain can range from minor to severe. The more severe your nerve injury, the more pain you may experience.

Q: Which nerves are affected by neuropathy?

A: Neuropathy affects three types of nerves, which are as follows:

  • Motor nerves are the nerves that control the conscious movement of muscles (like walking and talking)
  • Sensory nerves are nerves that convey information such as touch, temperature, and pain throughout the body.
  • Autonomic nerves are the nerves that control your body’s subconscious processes (like breathing and digesting food)

Q: How do doctors determine neuropathy?

A: Diagnosis of neuropathy might be difficult. Patients have varied symptoms, and the degree of those symptoms might vary even within the same patient. Doctors assess a patient’s medical history, perform a physical and neurological exam, take body fluid testing, and undertake genetic studies to diagnose neuropathy. Some clinicians prescribe nerve conduction velocity (NCV) tests to determine the intensity of nerve signals. Other doctors may order a nerve biopsy, electromyography (EMG), or a neuro-diagnostic skin biopsy.

Q: How can I avoid neuropathy?

A: The most superb method to avoid neuropathy is to start preventing it now. Most folks can avoid neuropathy. Diabetes is the leading cause of neuropathy in the United States, although diabetes is avoidable in most people. Many people can avoid neuropathy by just decreasing weight. Consult your doctor about neuropathy preventive methods.

Q: Is neuropathy inherited?

A: Over 100 different forms of neuropathy have been found, with some of them being genetic. A kind of neuropathy known as Charcot-Marie-Tooth disease, for example, is regarded as a genetic nerve condition. However, most neuropathy is caused by environmental causes rather than genetics.

Q: Can pre-diabetes lead to neuropathy?

A: Diabetics are prone to neuropathy. Pre-diabetics, on the other hand, may develop neuropathy as well. If your blood sugar levels are higher than average, you may be pre-diabetic and at a higher risk of getting neuropathy.

Best Nerve Supplements of 2021 Conclusion

Millions of people suffer from neuropathy, a painful condition. Some people take nerve pain or neuropathy supplements to help them. Nerve discomfort and nerve injury have the potential to alter your life drastically. It doesn’t matter where the anguish comes from; what matters is the devastating impact on a person’s life. You can boost nerve health throughout your body by using the correct neuropathy supplement. Again, any of these top nerve health supplements for neuropathy support should assist users in overcoming pain and discomfort.

More Like This: Nerve Rejuv Reviews – Do Golden After 50 Nerve Health Pills Work?

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.